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EC number: 203-794-9
CAS number: 110-71-4
Several acute toxicity studies were performed applying all exposure routes: oral, inhalation , and dermal.Oral:- female rats, LD50: 5370 mg/kg bw- female rats, LD50: > 4000 mg/kg bw- female mice, LD50: 2526 mg/kg bwInhalation:- male/female rats, LC0 (1h exposure): 240 mg/L -> 60 mg/L (4h calculated exposure)- rats, LC50 (6h exposure): > 20 mg/L- female rats, LC0 (1h exposure): 247 mg/L -> 61.8 mg/L (4h calculated exposure)Dermal:- female rats, LD50: > 5000 mg/kg bw- rabbits, LD50 ca. 2000 mg/kg bw
One key study plus supporting information is available in rats and mice for the acute oral toxicity of Ethylene glycol dimethyl ether. The most reliable LD50determined was 5370 mg/kg bw for rats.
A number of studies/supporting information is available for the acute inhalation toxicity in rats. The LC50 for 6 hours exposure is reported to be greater than 20 mg/L. Additionally two studies showed that the LC0 for 1 hour exposure to a saturated Ethylene glycol dimethyl ether atmosphere is set at 240 mg/L air. This leads to a calculated LC0value of 60 mg/L for 4 hours exposure.
There is one well performed and reported dermal toxicity study in female Wistar rats available. The LD50was reported to be > 5000 mg/kg bw. This information is supported by a restricted reported dermal toxicity study in female rabbits which led to a LD50of approximately 2000 mg/kg bw.
Due to the findings described above (LD50 oral in rats of 5370 mg/kg bw, LC50 inhalatory in rats greater than 20 mg/L, LD50 dermal in rats greater than 5000 mg/kg bw) Ethylene glycol dimethyl ether has not to be classified as acute toxic.
However, the substance is Annex 1 listed and classified as "harmful by inhalation " (R20).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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