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EC number: 203-794-9
CAS number: 110-71-4
A read across to Diethylene glycol methyl ethyl ether was performed. Diethylene glycol methyl ethyl ether has been tested negative in one Local Lymph Node Assay to assess the sensitising potential of the test item.
A read across to Diethylene glycol methyl ethyl ether was performed. Diethylene glycol methyl ethyl ether has been tested in one Local Lymph Node Assay to assess the sensitising potential of the test item.
Skin sensitising potential of Diethylene glycol methyl ethyl ether was tested in one Local Lymph Node Assay (LLNA) according to OECD test guideline 429. In this assay S.I. of 0.73, 1.03 and 0.69 were determined with the test item at concentrations of 25%, 50% and 100% in acetone:olive oil (4 +1).
In this assay no EC3 value could be calculated since all S.I. values were below 3. Due to structural and toxicological similarity between Diethylene glycol methylethyl ether and Ethylene glycol dimethyl ether a read across is regarded as acceptable for the target substance.
Based on the existing data it is concluded that the substance is not a respiratory sensitizer. There are no respiratory sensitization properties of the substance known in literature. Beyond this there is no hint of any sensitization property of the compound from the LLNA study. Therefore, it is concluded that the subsance is not a respiratory sensitizer.
Ethylene glycol dimethyl ether and Diethylene glycol methyl ethyl ether, which is tested for its sensitising potential, belong to the glycol ether family. These substances have been demonstrated to be very similar in structure, physical/chemical properties and the toxicological profile. Due to the fact that Ethylene glycol dimethyl ether and Diethylene glycol methyl ethyl ether have nearly the same chemical structure (especially with reference to the functional groups):
1. Ethylene glycol dimethyl ether: H3C-O-CH2-CH2-O-CH3
2. Diethylene glycol methyl ethyl ether: H3C-O-CH2-CH2 -O -CH2-CH2-O-CH2-CH3
the same mode of interaction with living cells and tissue is expected. Therefore, a read across from Ethylene glycol dimethyl ether to data obtained with Diethylene glycol methyl ethyl ether is scientifically justified.
Diethylene glycol methyl ethyl ether did not show skin sensitizing properties in the LLNA study according to the current OECD guidelines. Allergic skin reactions or case reports of acute contact dermatitis to Ethylene glycol dimethyl ether have not been described in the literature. Therefore, Ethylene glycol dimethyl ether does not have to be classified as a skin sensitizer.
A classification concerning respiratory sensitizing properties is not warranted as the classification criteria according to EU regulation 1272/2008 are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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