1,2-dimethoxyethane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1979

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: U.S. EPA peer reviewed robust summary of an acute inhalation toxicity study in which basic testing parameters are in line with the current guideline.

Data source

Reference

Reference Type:

other: U.S. EPA HPV Challenge Program

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

6 hours exposure

GLP compliance:

no

Remarks:

study performed before GLP implementation

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,2-dimethoxyethane

EC Number:

203-794-9

EC Name:

1,2-dimethoxyethane

Cas Number:

110-71-4

Molecular formula:

C4H10O2

IUPAC Name:

1,2-dimethoxyethane

Details on test material:

None

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

clean air

Details on inhalation exposure:

No further data

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

6 h

Concentrations:

20 mg/L
63 mg/L

No. of animals per sex per dose:

No data

Control animals:

no

Details on study design:

No data

Statistics:

None

Results and discussion

Preliminary study:

No data

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 20 - < 63 mg/L air

Exp. duration:

6 h

Mortality:

Please refer to "Remarks on results"

Clinical signs:

other: Please refer to "Remarks on results"

Body weight:

Please refer to "Remarks on results"

Gross pathology:

Please refer to "Remarks on results"

Other findings:

Please refer to "Remarks on results"

Any other information on results incl. tables

- 20 mg/L

Exposure to 20 mg/L for 6 hours produced only signs of irritation and slight ataxia. None of the animals died and all gained weight normally in the 14 -day observation period following exposure.

- 63 mg/L

Rats exposed to 63 mg/L showed signs of irritation at the beginning of exposure. This progressed to prostration after approximately 1.5 hours and they remained prostrate until the 6 -hour exposure was terminated. Although all of the animals survived the exposure, all of them died within 72 hours post-exposure.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Conclusions:

The median lethal concentration (LC50) of Ethylene glycol dimethyl ether after 6 hours inhalation is considered to greater than 20 mg/L.

Executive summary:

Two groups of rats were exposed to Ethylene glycol dimethyl ether vapor at concentrations of 20 and 63 mg/L.All animals from the 20 mg/L group survived the exposure and the 14 days post exposure period. All gained weight normally and no exposure related abnormalities were noted in those animals surviving 14 days. Rats exposed to 63 mg/L showed signs of irritation at the beginning of exposure. This progressed to prostration after approximately 1.5 hours and they remained prostrate until the 6 -hour exposure was terminated. Although all of the animals survived the exposure, all of them died within 72 hours post-exposure.

Based on this study the LC50 was estimated to be greater than 20 mg/L.