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EC number: 203-794-9
CAS number: 110-71-4
A 14 day inhalation toxicity study was performed in rats. The animals
were exposed to an Ethylene glycol dimethyl ether atmosphere of 100 ppm
(0.374 mg/L) and 1000 ppm (1.87 mg/L). All animals survived and no
clinical signs were noted at 100 ppm. No deaths or clinical signs
occurred in the rats of the 500 ppm dose group. Body weight gain of the
rats at 100 ppm exposure was unaffected. The body weight of the male
rats of the 500 ppm dose group was unaffected; the body weight of three
female rats was decreased. There were no effects upon the mean daily
food consumption observed in the 100 ppm dose group. Food consumption of
all females in the 500 ppm dose group was decreased. There were no
changes in haematology noted at 100 ppm. At 500 ppm the leucocyte count
was decreased in all animals. No macroscopic changes occurred in all
rats. The microsopic examination of the testes and epidymis showed
oligospermia at 100 ppm and severe lesions of the seminiferous
epithelium at 500 ppm exposure. At 100 ppm retardation of foetal
development was observed. At 500 ppm an increase of resorptions occurred.
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