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EC number: 203-794-9
CAS number: 110-71-4
A 14 day inhalation toxicity study was performed in rats. The animals were exposed to an Ethylene glycol dimethyl ether atmosphere of 0, 10 (0.037 mg/L), 50 (0.187 mg/L) and 250 ppm (0.935 mg/L).All animals survived and no clinical signs were noted at any dose level. No neurological or ophthalmological effects or changes in mucosa were noted. Body weight gain of all animals was not affected. There were no effects upon the mean daily food consumption observed at all dose levels. Water consumption of all females of the 50 ppm dose group was decreased from day 29 until termination of the study. Water consumption of all females of the 250 ppm dose group was decreased on study day 22 and 50. There were no haematological changes noted at any dose level.All determined clinical parameters were within the control range. Relative organ weights were within the control range.
No changes occurred at any dose level with the exception of the reduction of cell layers ofseminiferous epithelium in male rats of the 250 ppmdose group. This effect was reversible. There were no such findings in the recovery group.
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