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EC number: 203-794-9
CAS number: 110-71-4
Ethylene glycol dimethyl ether was tested for its skin irritant properties in 6 Himalayan rabbits. The study was performed according to OECD Guideline 404. Deviations were the absence of the recovery period of 14 days and a prolonged exposure period (24 hours). These conditions make the study design more rigid compared to the regarding OECD Guideline. Effects skin (erythema grades up to 4 and edema scores up to 2) were observed in all animals 48 hour after application. These signs were not reversible within the 72 hours observation period.
With reference the reported scores and the absence reversibility of the observed effects Ethylene glycol dimethyl ether has to be classified as irritant to the skin ( H315 - causes skin irritation, skin irritant category 2) according to the criteria laid down in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
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