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EC number: 203-794-9
CAS number: 110-71-4
A bacterial reverse mutation assay (Ames test) has been performed
on Ethylene glycol dimethyl ether covering the strains Salmonella
typhimurium TA98, TA100, TA1535, TA1537, TA1538 and E. coli WP2
uvr A. There was no increase in the number of revertant colonies with
any of the tester strains.
In two mammalian cytogenicity studies the genotoxic potential of
Ethylene glycol dimethyl ether was examined in vitro using
Chinese hamster cells for the detection of sister chromatid exchanges
and the permanent human cell line A549 for determination of unscheduled
DNAsynthesis, negative results in the absence of metabolic activation
were obtained for the human cell line and positive in case of the
Chinese hamster cells. Ethylene glycol dimethyl ether did not induce
chromosome aberrations at 2000 mg/kg bw in an in vivo Mammalian
Bone Marrow Chromosome Aberration test performed with hamsters similar
to OECD475. Furthermore, Ethylene glycol dimethyl ether is considered to
be non-mutagenic in mice in the micronucleus test applying dosages up to
2000 mg/kg d (at 2 applications on 2 consecutive days).
It can be concluded from the data available that mutagenicity and
genotoxicity are not caused by Ethylene glycol dimethyl ether and
therefore classification for this end point is not warranted.
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