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EC number: 203-794-9 | CAS number: 110-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.1 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 30
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Workers:
According
to RIP 3.2.2, Chapter R8, R8.1.2.5, p. 16 no acute DNELs were derived
since no acute toxicity hazard has been identified. The long-term DNEL
concerning reprotoxic (developmental) effects also covers possible acute
toxic effects.
Long-term dermal systemic DNEL based on NOAEC (14 d,
inhalation) in rats:
- derived systemic NOAEL: 132.6 mg/kg bw/d (for calculation details
please refer to Endpoint summary“Reproductive toxicity”)
- NOAEL(dermal) derived according to “Guidance on information
requirements and chemical safety assessment”, Chapter R8-2, Example B.5
(p. 69).
corrected NOAEL(dermal) = NOAEL(systemic, rat) x
Absorption(inhal-rat)/Absorption(dermal-human)
= 132.6 mg/kg bw/d x
100%/100%
= 132.6 mg/kg bw/d
- DNEL(dermal) derived from corrected NOAEL(dermal) applying the
assessment factor 120 (4(interspecies rat-human) x 5(intraspecies
worker) x 6(subacute-chronic))
=> =1.1 mg/kg bw/d
Long-term inhalatory DNEL based on NOAEL (14 d,
inhalation) in rats:
- NOAEC(inhalation) derived according to “Guidance on information
requirements and chemical safety assessment”, Chapter R8.4, Figure 8-2
(p. 27).
corrected
NAEC(inhalation) = NOAEC(inhal., rat) x 6(h/d)/8(h/d) x 6.7 m3/10 m3
= 187 mg/m3x
6(h/d)/8(h/d) x 6.7 m3/10 m3
= 94.0 mg/m3
- DNEL(inhalation) derived from corrected NOAEC(inhalation)
applying the assessment factor 30 (5(intraspecies) x 6(subacute-chronic))
=>= 3.1 mg/m3
The 14 days inhalation study in rats was chosen for the long-term DNEL derivation for workers since the rat is the commonly accepted and best investigated species for repeated dose toxicity studies. Furthermore, it can be assumed that workers are trained in handling chemicals and according to general occupational health regulations an exposure of pregnant workers to Ethylene glycol dimethyl ether at the production site is excluded. Ethylene glycol dimethyl ether is labeled as reprotoxic and teratogenic.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
DNEL related information
- Overall assessment factor (AF):
- 10
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.23 mg/kg bw/day
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
DNEL related information
- Overall assessment factor (AF):
- 24
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.23 mg/kg bw/day
- Most sensitive endpoint:
- developmental toxicity / teratogenicity
DNEL related information
- Overall assessment factor (AF):
- 24
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
According to RIP 3.2.2, Chapter R8, R8.1.2.5, p. 16 no acute DNELs were derived since no acute toxicity hazard has been identified. The long-term DNEL concerning reprotoxic (developmental) effects also covers possible acute toxic effects.
Long-term oral systemic DNEL based on NOAEC (14d,
inhalation teratognicity study) in rabbits: 5.6 mg/kg bw/d
(for calculation details please refer to Endpoint summary“Reproductive
toxicity”)
applying assessment factor 24 (2.4(interspecies rabbit-human) x 10
(intraspecies general population))
=> =0.23 mg/kg bw/d
Long-term dermal systemic DNEL based on NOAEC (14 d,
inhalation teratogenicity study) in rabbits:
- derived systemic NOAEL: 5.6 mg/kg bw/d (for calculation details please
refer to Endpoint summary“Reproductive toxicity”)
- NOAEL(dermal) derived according to “Guidance on information
requirements and chemical safety assessment”, Chapter R8-2, Example B.5
(p. 69).
-corrected NOAEL(dermal)
= NOAEL(systemic, rabbit) x Absorption(inhal-rabbit)/Absorption(dermal-human)
= 5.6 mg/kg bw/d x 100%/100%
= 5.6 mg/kg bw/d
- DNEL(dermal) derived from corrected NOAEL(dermal) applying the
assessment factor 24 (2.4(interspecies rabbit-human) x 10(intraspecies
general population))
=> =0.23 mg/kg bw/d
Long-term inhalatory DNEL based on NOAEC (14 d, inhalation teratogenicity study) in rabbits:
- NOAEC(inhalation) derived according to “Guidance on information requirements and chemical safety assessment”, Chapter R8.4, Figure 8-2 (p. 27).
corrected NAEC(inhalation) = NOAEC(inhal., rabbit) x 6(h/d)/24(h/d)
= 60 mg/m3x 6(h/d)/24(h/d)
= 15.0 mg/m3
- DNEL(inhalation) derived from corrected NOAEC(inhalation) applying the assessment factor 10(intraspecies)
=>= 1.5 mg/m3
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