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EC number: 273-227-8
CAS number: 68953-84-4
A 4 -week toxicity study was conducted in rats at levels of 120, 470 &
1900 ppm in the diet. The study was similar to various guidelines and
was conducted per GLPs. Macrocytic
anemia was the primary change in rats related to chemical exposure.
These changes were reversible within 2 weeks following dietary exposure
cessation, as were liver weight and serum cholesterol elevations. These
changes were minor, and were associated with no apparent prolonged
adverse effects. Based upon these findings, the NOEL for test chemical
in rats was ~7.5 mg/kg bw/day (120 ppm in the diet). The
PCNA data for liver and bladder indicated increased cellular division at
the higher doses, but the lack of dose-responsiveness provides results
of uncertain importance to the assessment of the toxicity of this
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