Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-227-8
CAS number: 68953-84-4
A 4 -week toxicity study was conducted in rats at levels of 120, 470 &
1900 ppm in the diet. The study was similar to various guidelines and
was conducted per GLPs. Macrocytic
anemia was the primary change in rats related to chemical exposure.
These changes were reversible within 2 weeks following dietary exposure
cessation, as were liver weight and serum cholesterol elevations. These
changes were minor, and were associated with no apparent prolonged
adverse effects. Based upon these findings, the NOEL for test chemical
in rats was ~7.5 mg/kg bw/day (120 ppm in the diet). The
PCNA data for liver and bladder indicated increased cellular division at
the higher doses, but the lack of dose-responsiveness provides results
of uncertain importance to the assessment of the toxicity of this
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again