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EC number: 273-227-8
CAS number: 68953-84-4
Average % (S.Dev.) Distribution of 14C
Following R-898 Dosing to Rats*
* n = 6
Radio-labelled (14C) dimethyl component of DAPD (R-898) was dermally and
intravenously administered to female rats. The latter served as
benchmark for 100% absorption of test material. Collection of urinary &
fecal exretion demonstrated 70% recovery of radioactivity following iv
dosing whereas recovery of 88% of dermally-applied test compound was
achieved. The latter included skin site rinses, tape stripping and skin
digestion samples to recover unabsorbed topically-applied residues.
Comparison of excreted radioactivity from groups of rats following
dermal application versus iv dosing indicated 60% of the
dermally-applied test chemical was absorbed during the 7 -day study. The
bulk (>95%) of absorbed test chemical was excreted via the feces.
Percutaneous uptake of chemicals by rats is known to be substantially
higher than that for primates including humans.
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