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EC number: 273-227-8
CAS number: 68953-84-4
1) WoE: A short term fish test (K4) (48h) was performed with Orange killifish (Oryzias latipes) according to the Japanese Industrial standard (JIS K 0102-1993-71 & GLP); LC50 (48h) = 17.2 mg/L 2) WoE: A short-term fish test (K2) (7d) was performed with Rainbow trout (Oncorhynchus mykiss), however not according to any specific guideline. 3) WoE: A prolonged fish toxicity test (14 days) (OECD 204 & GLP) (K1) with Rainbow trout (Oncorhynchus mykiss) provided valuable information on the acute toxicity; EC50 (4d, mortality) = 0.48 mg/L; NOEC (4d) = 0.14 mg/L (WoE) 4) WoE: A prolonged fish toxicity test (14 days) (OECD 204 & GLP) (K1) with Common Carp (Cyprinus carpio) provided valuable information on the acute toxicity; EC50 (4d, mortality) > 0.67 mg/L; NOEC (4d) = 0.28 mg/L (WoE)
are two test reports available describing acute toxicity to fish
(Tadokoro, 1998; Dionne, 1997). Both studies were performed as
range-finder tests for long-term fish toxicity studies. Consequently,
concentrations were not analytically confirmed for all test conditions
and therefore results display a certain level of uncertainty. Besides
the actual acute test reports, the prolonged fish tests (OECD 204)
performed on Rainbow trout (Oncorhynchus mykiss) (Dionne, 1997)
and common carp (Cyprinus carpio) (Dionne, 1995) also provided
very useful information on the short term toxicity of 1,4-benzenediamine,
N,N'-mixed Ph and tolyl derivs. since 96h-LC50 values are 0.48 and >
0.67 mg/L, while NOECs (96h) are 0.14 and 0.28 mg/L for trout and carp,
respectively. The concentrations used in these tests were analytically
verified and since both tests were performed according to the OECD and
GLP guidelines, the test results gathered in these tests were used for
further risk assessment and classification purposes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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