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EC number: 273-227-8
CAS number: 68953-84-4
1) Key study: Chronic (56 days) toxicity to eartworms (Eisenia fetida); K1; 2010; OECD 222; GLP; NOEC = 1000 mg/kg dry soil (mortality, growth and reproduction)2) Supporting study: Acute (14 days) toxicity to earthworms (Eisenia fetida); K2; 2010; OECD 207; non-GLP; no toxicity determined up to 1000 mg/kg dry soil (mortality and growth).
In a first range finder study, the acute
toxicity towards earthworms (Eisenia fetida) exposed to
chemically-treated artificial soil at levels of 0.1, 1.0, 10, 100 & 1000
mg/kg dry soil for 14 days was evaluated (McCormac, 2010). This study
was performed according to OECD guideline 207, but not according to GLP
guidelines. Adult worms were monitored for lethality and body weight
changes during the exposure period. No effects were observed on either
one of these endpoints. The NOEC (14d) was determined at 1000 mg test
chemical/kg dry soil (nominal values) for both endpoints (growth and
Subsequent to the acute toxicity study (OECD
207), a 56 -day chronic toxicity study (OECD 222; McCormac, 2010) was
performed to assess the impact of DAPD levels on the earthworm Eisenia
fetida. This study was compliant to both the OECD and GLP
guidelines. Compound levels added to soil were 125, 250, 500, and 1000
mg test chemical/kg dry soil (nominal values). No chemical analysis was
performed in this study due to the high degree of adsorption of this
chemical to soil shown by the OECD 121 study (Koc > 4.3) (Drake, 2010)
and the low degree of chemical migration shown in a soil field study
(McLaughlin, 1997). Earthworm mortality and body weight changes were
monitored after 28-day exposure period. Egg cocoons that were observed
at Day 28 were returned to the treated soil to allow hatching. Numbers
of juveniles appearing by Day 56 were recorded as unhatched cocoons.
There were no statistically significant changes resulting from DAPD
exposures towards worm mortality, body weight changes, appearances of
juveniles or unhatched cocoons during the 56 day study. Therefore, the
NOEC was determined at 1000 mg test chemical/kg dry soil (endpoints:
mortality, growth, reproduction).
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