Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-194-7
CAS number: 6425-39-4
In a Buehler test according to OECD Guideline 406, the test substance
was observed not to be sensitising to the skin (Lemoncelli, 2012).
There were no signs of systemic toxicity and all animals gained weight
during the main study.
The positive control group, induced and challenged with DNCB, exhibited
the anticipated positive responses at challenge, indicating that the
methods employed in this study were valid.
All dermal irritation scores at the 24- and 48 -hour observations were
zero for the vehicle control animals challenged with the test article
and the vehicle (saline).
A single score of ± was recorded in the test article group at the test
article site at 24 hours. All dermal irritation scores at the 48 -hour
observations were zero for the test article group challenged with the
test article and the vehicle (saline).
Lemoncelli (2012) investigated the sensitising properties of the test
substance in a buehler test with male and female Hartley guinea pigs.
The study examined the skin sensitising effect on guinea pigs, using 4
animals in the dose range finding test, 20 animals in the test article
group, 10 animals in the vehicle control group and 6 animals in the
positive control group. Under the conditions of this study, induction
with the substance as received did not elicit a delayed contact
hypersensitivity response in guinea pigs when challenged as received.
Based on the study results and the criteria of the CLP Regulation, the
test substance should not be classified as skin sensitising substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again