Registration Dossier

Physical & Chemical properties

Dissociation constant

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-07-11
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Well performed GLP study in accordance with OECD Guideline 112.
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: PFW100113
- Analytical purity: 99.3% (by GC)

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: the sample is stored in cool, well-ventilated storage area prior to testing.

OTHER SPECIFICS:
- Name of test material (as cited in study report): Jeffcat DMDEE
- Physical state: Liquid
Dissociating properties:
yes
No.:
#1
pKa:
6.8
Temp.:
20 °C
Remarks on result:
other: No details on temperature are provided, however ambient temperature is anticipated
Conclusions:
The dissociation constant of the substance was determined to be 6.8 ± 0.5.

Description of key information

The dissociation constant of the test substance was determined to be 6.8 at ambient temperature following a GLP study conducted in accordance with guideline OECD 112 using the titration method (Younis, 2011).

Key value for chemical safety assessment

pKa at 20°C:
6.8

Additional information

Although the temperature was not reported it was assumed that the study was conducted at ambient temperature.