Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-194-7
CAS number: 6425-39-4
Acute toxicity: oral:A K2 acute oral toxicity test was performed in male and female Crl:COBS CD(SD)BR rats according to a guideline similar to OECD Guideline 401 (Huntsman, 1978). This study was selected as key study. Acute toxicity: inhalationNo reliable acute inhalation test was available for DMDEE. Only a K4 study is available for acute inhalation tested in male and female Sprague Dawley rats (Huntsman, 1978). The test was performed according a guideline equivalent to OECD Guideline 403.Acute toxicity: dermalA K2 acute dermal test was performed in male and female New Zealand White rabbits according to a guideline similar to OECD Guideline 402 (Huntsman, 1978). This study was selected as key study.
Acute toxicity: oral
Huntsman (1978) investigated the acute oral toxicity via gavage of
118.5, 400, 1350, 2025, 3038 and 4556 mg/kg bw test substance in 4
Crl:COBS CD (SD) BR male/female rats. After 14 days of observation,
mortality has been observed: 2025 mg/kg group: 2/4 dead (1 female
between 6-22h and 1 female after 1.5 days), 3038 mg/kg group: 4/4 dead
(1 male and 1 female between 6-22h, 1 male after 1 day, 1 female after 2
days), 4556 mg/kg group: 4/4 dead (2 males after 4.5 days, 2 females
between 6-22h). The acute oral LD50 was determined to be 2025 mg/kg bw.
This study is designated as key study. In addition, two supporting K1
and K4 studies reported a LD50 value of > 2000 mg/kg bw and 2.83 mL/kg
bw (3000 mg/kg bw), respectively.
Acute toxicity: inhalation
No reliable studies were available for the inhalation route. A waiver
statement was added and justified as following: next to the oral route
of exposure, for substances other than gases, the information mentioned
under 8.5.2 to 8.5.3 shall be provided for at least one other route
(REACH Regulation, column 2 adaptation of Annex VIII). For this
substance, a key study is available for the dermal route of exposure.
Therefore, an acute inhalation toxicity study should not be performed.
Acute toxicity: dermal
Huntsman (1978) investigated acute dermal toxicity of the test substance
in 4 New Zealand White male/female rabbits after 24 hours of exposure to
respectively 1350, 2025, 3038 and 4556 mg/kg bw. No mortality was
observed at 1350 or 2025 mg/kg bw/d. In the 3038 mg/kg bw 2 animals out
of 4 died. All animals (4/4) died in the 4556 mg/kg bw dosing group.
Therefore, after 14 days of observation, an LD50 value of 3038 mg/kg bw
was reported. This study is designated as key study. In addition, a
supporting K4 study reported a LD50 value of 0,704 mL/kg bw (746 mg/kg
Based on the available data and according to the criteria of the CLP
Regulation, the test substance should not be classified as acute toxic
via the oral and dermal route. No data were available to decide on the
classification via the inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again