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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1996-02-16 to 1996-03-08
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Well documented non GLP study performed according to OECD Guideline 117 (HPLC method).
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 6995-74-38
- Analytical purity: 99.612%
- Impurities (identity and concentrations): DMORE 0.02%

OTHER SPECIFICS:
- Name of test material (as cited in study report): DMDEE, bis(2-morpholinoethyl)-ether
- Substance type: Yellow-brown liquid
- Physical state: Liquid
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
0.5
Temp.:
25 °C
pH:
9
Details on results:
Regression equation of calibration curve in measurement conditon:
log Pow = 0.957 + 1.696 x log K
r =0.999
Partition coefficient: log Pow = 0.5 (average of 2 measured values)
Conclusions:
The log Pow of the test substance was determined to be 0.5 at 25°C and pH 9.

Description of key information

The log Pow of the test substance was determined in a non GLP study according to OECD Guideline 117 to be 0.5 at 25 °C, following the HPLC method (Furutani, 1996).

Key value for chemical safety assessment

Log Kow (Log Pow):
0.5
at the temperature of:
25 °C

Additional information

The test was performed at pH 9. Under these test conditions, it is anticipated that the substance is predominantly in its non-ionized form.