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EC number: 600-033-6
CAS number: 1001416-18-7
The potential of the substance to induce
mutations was assessed in a bacterial reverse mutation assay. The study
was conducted in accordance with OECD Guideline 471. The assay was
performed in two independent experiments. Both took place as a plate
incorporation test using the Salmonella typhimurium strains TA 1535, TA
1537, TA 98, TA 100 and TA 102. All experiments were in the absence and
in the presence of a metabolic activation by an Aroclor 1254 induced
rat liover post mitochondrial fraction (S9). Five concentrations were
tested in each experiment using 0.1 ml for each plate. No mutagenic
effects occurred with or without metabolic activation in experiment 1
(313, 625, 1250, 2500 and 5000 µg/plate). Precipitation was observed at
a concentration >= 1250 µg/plate at all tester strains. In experiment 2
(125, 250, 500, 750, 1000 µg/plate) no mutagenic or toxic effects
occurred. Precipitation was not observed at any concentration.
It can be concluded that the test substance
did not induce gene mutations by base pair substitution or frame shifts
in the genom of the used strains. Therefore the test substance is
considered to be non mutagenic in the bacterial reverse mutation assay.
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