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EC number: 600-033-6
CAS number: 1001416-18-7
primary dermal irritation index (PDII) (mean of three animals): Score: 1
The skin irritation potential of the
substance was assessed by semi-occluded application of the substance for
four hours to the shorn skin of two female and one male rabbit, strain
New Zealand White according to OECD Guideline 404. Dermal reactions at
the treated skin sites were assessed 1 hour after removal of the test
substance and approximately 24, 48 and 72 hours as well as 7 and 14 days
later. Systemic toxicity symptoms after application were not observed at
any time during the study. Body weight development of the animals was
positive and within normal ranges.
The substance elicited slight erythema
formation at two animals after 1 hour and 24 hours after removal of the
substance which was still observed in one animal after 48 hours. 72
hours after the removal of the substance no more erythema were observed
in all three animals. A mean score of 0.67, 0.33 and 0 was allocated.
Oedema formation was not observed at any time point.
7 days after application desquamation
was observed at the treated skin of one animal. 14 days after
application slight desquamation was still existent.
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