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EC number: 229-713-7
CAS number: 6674-22-2
See "Attached background material".
1,8-Diazabicyclo[5.4.0]undec-7-ene was administered by gavage to groups
of 10 male and 10 female Wistar rats at dose levels of 0 (test group 0),
15 (test group 1), 40 (test group 2) and 120 mg/kg bw/d (test group 3)
over a period of 3 months.
With regard to clinical examinations, signs of general systemic toxicity
were not observed up to the highest dose tested 120 mg/kg bw/d.
Concerning clinical pathology no treatment-related, adverse effects were
observed up to a dose of the test substance of 120 mg/kg bw/d.
Regarding pathology, all findings occurred either individually or were
biologically equally distributed over control and treatment groups. They
were considered to be incidental or spontaneous in origin and without
any relation to treatment.
All other findings occurred either individually or were biologically
equally distributed over control and treatment groups. They were
considered to be incidental or spontaneous in origin and without any
relation to treatment.
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