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EC number: 229-713-7
CAS number: 6674-22-2
In a prenatal developmental toxicity study the test substance
1,8-Diazabicyclo[5.4.0]undec- 7-ene was administered to pregnant Wistar
rats daily by gavage from implantation to one day prior to the expected
day of parturition (GD 6-19) to evaluate its potential maternal and
prenatal developmental toxicity. Analyses confirmed the correctness of
the prepared concentrations and the stability of the test substance in
the vehicle. Generally, clinical observations including food consumption
and body weight/body weight gain revealed no toxicologically relevant
differences between the animals receiving 15, 50 and 150 mg/kg bw/d
1,8-Diazabicyclo[5.4.0]undec-7-ene and controls. No differences of
toxicological relevance between the control and the treated groups (15,
50 or 150 mg/kg bw/d) were determined for any reproductive parameters,
such as conception rate, mean number of corpora lutea, mean number of
implantations, as well as pre- and postimplantation loss. Similarly, no
influence of the test substance on fetal weight and sex distribution of
the fetuses was noted at any dose. Overall, there was no evidence for
toxicologically relevant adverse effects of the test substance on fetal
morphology at any dose.
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