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EC number: 229-713-7
CAS number: 6674-22-2
No further data
corrosivity potential of DBU was evaluated using the Corrositex assay.
The Corrositex assay is a standardized and quantitative in vitro
corrosivity test. It is based on the time that is required for the test
sample to pass through a biobarrier membrane and produce a colour change
in the chemical detection system. The Corroxitex Biobarrier Membrane
consists of a reconstituted matrix.
of the potential corrosivity of the test article was measure by its
penetration through a calibrated biobarrier into a chemical detection
system. The test article was tested in at least one definitive assay
(six replicates) to determine the packing group and the mean break
to the main test, the ability of the test article to produce a change in
the chemical detection system when added directly was determined.
experimental design of this study consisted of a pH determination, and a
definitive Corrrositex assay in the chemical detection system. The
Corrositex assay was evaluated on the basis of the colour change of the
chemical detection system. The time that a colour change was observed
was recorded manually and the average of the six replicates was used to
determine the packing group.
hydroxide (NaOH) was used as a positive control and colour was used as a
blank (negative control).
test article was administered by direct addition to the membrane disc
which was placed onto a vial containing the chemical detection system.
The vial was observed continuously for ten minutes and then at one and
four hours after addition of the test material to record any changes in
the chemical detection system. The first indication of the presence of
the test article was detected as a colour change in the chemical
detection system as compared to the blank control. The time of this
change was recorded. The packing group was determined by the time
interval the sample took to break through the biobarrier matrix.
break through time for DBU ranged from 18 – 22 minutes with an average
of 20 minutes based on six replicates. The pH of DBU was reported as
14.0 and it was designated in packing group II.
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