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EC number: 229-713-7
CAS number: 6674-22-2
Clinical signs (males):
Dose (mg/kg bw)
Poor general state
0 h – 5 h
0 h – 1 h
Clinical signs (females):
Mean body weight (males):
Mean body weight (females):
Groups of Wistar rats (5/sex) were gavaged with DBU (in water) at dose
levels of 215, 681 or 2000 mg/kg bw and observed for 14 days. Deaths
occurred at 2000 mg/kg bw (10/10) and at 681 mg/kg bw (9/10). Signs of
toxicity (reduced general state, dyspnoea, apathy, abdominal position,
staggering, tremor, twitching, cyanosis, exophthalmos, atonia, paresis)
were also observed at these dose levels. No effects of treatment were
observed at 215 mg/kg bw. The acute oral LD50 of DBU in the rat was
therefore found to be 215 -681 mg/kg bw under the conditions of this
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