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EC number: 229-713-7
CAS number: 6674-22-2
No in vivo data are available for skin or eye irritation; however the pH of the substance indicates that corrosivity is likely and the corrosive properties of the substance have been confirmed experimentally in an in vitro skin corrosion study conducted using the Corrositex Packing Group Assay.
No further data
corrosivity potential of DBU was evaluated using the Corrositex assay.
The Corrositex assay is a standardized and quantitative in vitro
corrosivity test. It is based on the time that is required for the test
sample to pass through a biobarrier membrane and produce a colour change
in the chemical detection system. The Corroxitex Biobarrier Membrane
consists of a reconstituted matrix.
of the potential corrosivity of the test article was measure by its
penetration through a calibrated biobarrier into a chemical detection
system. The test article was tested in at least one definitive assay
(six replicates) to determine the packing group and the mean break
to the main test, the ability of the test article to produce a change in
the chemical detection system when added directly was determined.
experimental design of this study consisted of a pH determination, and a
definitive Corrrositex assay in the chemical detection system. The
Corrositex assay was evaluated on the basis of the colour change of the
chemical detection system. The time that a colour change was observed
was recorded manually and the average of the six replicates was used to
determine the packing group.
hydroxide (NaOH) was used as a positive control and colour was used as a
blank (negative control).
test article was administered by direct addition to the membrane disc
which was placed onto a vial containing the chemical detection system.
The vial was observed continuously for ten minutes and then at one and
four hours after addition of the test material to record any changes in
the chemical detection system. The first indication of the presence of
the test article was detected as a colour change in the chemical
detection system as compared to the blank control. The time of this
change was recorded. The packing group was determined by the time
interval the sample took to break through the biobarrier matrix.
break through time for DBU ranged from 18 – 22 minutes with an average
of 20 minutes based on six replicates. The pH of DBU was reported as
14.0 and it was designated in packing group II.
No in vivo studies are available on the eye or skin irritation effects
of the substance. In an in vitro skin corrosion study conducted using
the Corrositex Assay, the substance has been shown to be corrosive
(Packaging Group II) and a strong base (pH 14) in a Corrositex Packing
Group Assay. On the basis that the substance is a strong base and has
been shown to be corrosive in experimental systems, it can therefore be
predicted to be corrosive to skin and a severe eye irritant.
No in vivo studies of skin and eye irritation are available. Based on
the pH of the substance, evidence of corrosive effects from a Corrositex
Packing Group Assay and the designation of the substance in Packaging
Group II, classification for corrosivity is considered appropriate. The
substance is therefore classified as Skin Corrosive (Category 1B) H314:
causes severe skin burns and eye damage according to CLP Regulation EC
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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