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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: GLP-guideline study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1992
Reference Type:
secondary source
Title:
Methanesulfinic acid, Aminoimino, CAS No: 1758-73-2
Author:
OECD SIDS
Year:
2002
Bibliographic source:
OECD SIDS; UNEP Publications

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Aminoiminomethanesulphinic acid
EC Number:
217-157-8
EC Name:
Aminoiminomethanesulphinic acid
Cas Number:
1758-73-2
Molecular formula:
CH4N2O2S
IUPAC Name:
aminoiminomethanesulphinic acid
Test material form:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
air
Details on inhalation exposure:
Groups of 5 male and 5 female Sprague Dawley rats (Him:OFA) each were exposed for 4 hours to air containing 59, 117 and 229 mg formamidine sulfinic acid per m3 air in a nose-only inhalation device.
Analytical verification of test atmosphere concentrations:
yes
Remarks:
9 or 10 times determination of concentrations during each inhalation period
Duration of exposure:
4 h
Concentrations:
59, 117, 229 mg/m³
No. of animals per sex per dose:
female: 5
male: 5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
0.164 mg/L air (analytical)
Based on:
act. ingr.
Exp. duration:
4 h
Mortality:
In the high concentration group at 0.229 mg/L all animals died 1 or 2 days after treatment, whle in the low concentration group at 0.59 mg/L and in the mid concentration group at 0.117 mg/L no deaths were observed.
Clinical signs:
other: Observations in life included ruffled fur, chromodacryorrhea and difficulties in breathing in all mid and highdosed animals. In the low dose group difficulties in breathing were hardly detected. Anemia and cyanosis as well as low locomotion were found in
Body weight:
In the mid concentration group there was temporary loss of body weights during the first week.
Gross pathology:
At terminal necropsy no lesions were found in 5/10 animals of low-dosed group: in all other animals, haemorrhages or white coverings were found in the lungs, the severity depending on the concentration. Histopathology revealed a corrosive action of test compound in the lung as indicated by multifocal fibrosis, inflammation, proliferation, edema, congestion, loss of cilia etc. Some of these changes were present in the low-dose group and increased with increasing doses. Trachea and nasal cavity were also affected.

Applicant's summary and conclusion

Interpretation of results:
other: inconclusive
Remarks:
Criteria used for interpretation of results: EU
Executive summary:

Testing the inhalation toxicity of aqueous FAS aerosols resulted in a LC50 of 0,164 mg/l/4 hrs calculated as the geometric mean of the results at 0.229 mg/L with 100% and 0.117 mg/L with 0% death rates.