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EC number: 217-157-8 | CAS number: 1758-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Reference Type:
- secondary source
- Title:
- Methanesulfinic acid, Aminoimino, CAS No: 1758-73-2
- Author:
- OECD SIDS
- Year:
- 2 002
- Bibliographic source:
- OECD SIDS; UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Aminoiminomethanesulphinic acid
- EC Number:
- 217-157-8
- EC Name:
- Aminoiminomethanesulphinic acid
- Cas Number:
- 1758-73-2
- Molecular formula:
- CH4N2O2S
- IUPAC Name:
- aminoiminomethanesulphinic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- Groups of 5 male and 5 female Sprague Dawley rats (Him:OFA) each were exposed for 4 hours to air containing 59, 117 and 229 mg formamidine sulfinic acid per m3 air in a nose-only inhalation device.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- 9 or 10 times determination of concentrations during each inhalation period
- Duration of exposure:
- 4 h
- Concentrations:
- 59, 117, 229 mg/m³
- No. of animals per sex per dose:
- female: 5
male: 5 - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.164 mg/L air (analytical)
- Based on:
- act. ingr.
- Exp. duration:
- 4 h
- Mortality:
- In the high concentration group at 0.229 mg/L all animals died 1 or 2 days after treatment, whle in the low concentration group at 0.59 mg/L and in the mid concentration group at 0.117 mg/L no deaths were observed.
- Clinical signs:
- other: Observations in life included ruffled fur, chromodacryorrhea and difficulties in breathing in all mid and highdosed animals. In the low dose group difficulties in breathing were hardly detected. Anemia and cyanosis as well as low locomotion were found in
- Body weight:
- In the mid concentration group there was temporary loss of body weights during the first week.
- Gross pathology:
- At terminal necropsy no lesions were found in 5/10 animals of low-dosed group: in all other animals, haemorrhages or white coverings were found in the lungs, the severity depending on the concentration. Histopathology revealed a corrosive action of test compound in the lung as indicated by multifocal fibrosis, inflammation, proliferation, edema, congestion, loss of cilia etc. Some of these changes were present in the low-dose group and increased with increasing doses. Trachea and nasal cavity were also affected.
Applicant's summary and conclusion
- Interpretation of results:
- other: inconclusive
- Remarks:
- Criteria used for interpretation of results: EU
- Executive summary:
Testing the inhalation toxicity of aqueous FAS aerosols resulted in a LC50 of 0,164 mg/l/4 hrs calculated as the geometric mean of the results at 0.229 mg/L with 100% and 0.117 mg/L with 0% death rates.
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