Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The skin sensitising properties of aminoiminomethanesulphinic acid (CAS 1758-73-2) were tested in a guinea pig maximisation test similar to OECD Guideline 406 (Maurer, 1988).

In the study, Pirbright white guinea pigs (20/group) were induced with 3 pairs of intradermal injections of FCA, 1% test substance in saline and 1% test substance in FCA/saline-adjuvant. Epicutaneous induction was done by application of the test substance at 30% in Vaseline (white petroleum) on the injection site on Day 8. A negative control group was included in the study. Epicutaneous challenge exposure was conducted 20 days after the first induction for 24 h under occlusive conditions. The test substance was applied on the flank at a concentration of 3%. Evaluation of skin reactions was carried out 24 and 48 h after challenge. P-phenylenediammine / potassiumdichromate was included as positive control substance was included in the study.

No skin reactions were observed in any animal in the negative control group. Thus, the available data on skin sensitisation do not provide evidence for sensitising properties of aminoiminomethanesulphinic acid (CAS 1758-73-2) under the conditions of the study.

 

Migrated from Short description of key information:

OECD 406: non sensitsing

Justification for selection of skin sensitisation endpoint:

There is only one study available.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

Justification for selection of respiratory sensitisation endpoint:

Study not required according to Annex VII-X of Regulation (EC) No 1907/2006.

Justification for classification or non-classification

The available data on the skin sensitisation of aminoiminomethanesulphinic acid (CAS 1758-73-2) do not meet the criteria for classification according to Regulation (EC) No 1272/2008 or Directive 67/548/EEC.