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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Testing conducted according to GLP and to a standard method, details not yet available

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Methanesulfinic acid, Aminoimino, CAS No: 1758-73-2
Author:
OECD SIDS
Year:
2002
Bibliographic source:
OECD SIDS; UNEP Publications
Reference Type:
study report
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Details on dermal exposure:
5 male and 5 female Sprague Dawley rats (Him:OFA) were hair-clipped and received 1 day later a dermal dose of 2000 mg formamidine sulfinic acid/kg body weight. Application was achieved by spreading the test substance over an area of approx. 5 x 6 cm and moistening with destilled water. The area was then covered by a cellulose patch for 24 hours.
Duration of exposure:
24 h
Doses:
2000 mg FAS/kg bw
No. of animals per sex per dose:
female: 5
male: 5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
not reported
Clinical signs:
The only adverse inlife- observation was chromodacryorrhea which occurred maximally 1 day after administration of the compound in all males and 4/5 females. This was attributed to reduced well-being caused by the dressing.
Body weight:
no effects reported
Gross pathology:
At necropsy no changes were observed that could unequivocally be attributed to the test compound.

Applicant's summary and conclusion

Interpretation of results:
other: inconclusive
Remarks:
Criteria used for interpretation of results: EU
Executive summary:

As result of the dermal toxicity tes in rats it is concluded that the LD50 (dermal) of formamidine sulfinic acid is beyond 2000mg/kg b.w.