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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Dec 1969 - Januar 1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Similar to guideline study with acceptable restrictions (no analytical purity reported)

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1970
Reference Type:
secondary source
Title:
Methanesulfinic acid, Aminoimino, CAS No: 1758-73-2
Author:
OECD SIDS
Year:
2002
Bibliographic source:
OECD SIDS; UNEP Publications

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
no analytical purity reported
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Aminoiminomethanesulphinic acid
EC Number:
217-157-8
EC Name:
Aminoiminomethanesulphinic acid
Cas Number:
1758-73-2
Molecular formula:
CH4N2O2S
IUPAC Name:
aminoiminomethanesulphinic acid
Test material form:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: S. Ivanovas, Kißlegg/Württ, Germany
- Weight at study initiation: 90-100 g (males; females)
- Fasting period before study: animals were fasted overnight prior to administration
- Housing: individual in Makrolon cage (type II)
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24 ± 0.5
- Humidity (%): 60 ± 3

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 1% aqueous solution of Tylose
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 3 mL/ kg bw

Doses:
Doses administered are not indicated.
No. of animals per sex per dose:
5
Control animals:
other: not required
Details on study design:
- Duration of observation period following administration: 4 weeks
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, grosspathology
Statistics:
LD 50 was calculated according to Litchfield and Wilcoxon

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 120 mg/kg bw
Based on:
test mat.
Remarks on result:
other: "Toxicity threshold" is reported to be approximately at 900 mg/kg.
Mortality:
Death occured within 18 to 72 h.
Clinical signs:
other: Signs of intoxication were sedation, ataxia, lying on belly or flank, hypoventilation and reduced reflexes beginning after 6 to 8 h. Survinng animals recovered within 1-4 days.
Gross pathology:
After necropsy there was possibly lung edema and distribution of blood disorders in liver.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP: Acute Oral 4, H302
DSD: Xn, R22