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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Dec 1969 - Januar 1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Similar to guideline study with acceptable restrictions (no analytical purity reported)

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1970
Reference Type:
secondary source
Title:
Methanesulfinic acid, Aminoimino, CAS No: 1758-73-2
Author:
OECD SIDS
Year:
2002
Bibliographic source:
OECD SIDS; UNEP Publications

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
no analytical purity reported
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: S. Ivanovas, Kißlegg/Württ, Germany
- Weight at study initiation: 90-100 g (males; females)
- Fasting period before study: animals were fasted overnight prior to administration
- Housing: individual in Makrolon cage (type II)
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24 ± 0.5
- Humidity (%): 60 ± 3

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 1% aqueous solution of Tylose
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 3 mL/ kg bw

Doses:
Doses administered are not indicated.
No. of animals per sex per dose:
5
Control animals:
other: not required
Details on study design:
- Duration of observation period following administration: 4 weeks
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, grosspathology
Statistics:
LD 50 was calculated according to Litchfield and Wilcoxon

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 120 mg/kg bw
Based on:
test mat.
Remarks on result:
other: "Toxicity threshold" is reported to be approximately at 900 mg/kg.
Mortality:
Death occured within 18 to 72 h.
Clinical signs:
Signs of intoxication were sedation, ataxia, lying on belly or flank, hypoventilation and reduced reflexes beginning after 6 to 8 h. Survinng animals recovered within 1-4 days.
Gross pathology:
After necropsy there was possibly lung edema and distribution of blood disorders in liver.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP: Acute Oral 4, H302
DSD: Xn, R22