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Diss Factsheets
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EC number: 217-157-8 | CAS number: 1758-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Test method details not published
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicologic characteristics of thiourea and its dioxide
- Author:
- Zhislin LE, Ovetskaia NM
- Year:
- 1 972
- Bibliographic source:
- Gig Tr Prof Zabol. 1972, Jun; 16(6) 51-52 (russ.) (Gigiena truda i professional'nye zabolevaniia] Toxline citation: http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~d3hGJg:3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The author' own guideline
- Principles of method if other than guideline:
- LD50 was determined by intraperitoneal injection to white rats of aqueous solutions of the substances by probit analysis and in modification by V.B. Prozorovskiy when observed during 14 days. To characterize the cumulative properties of the two groups of rats 10 in each every day for 20 days, 1/5 LD50 thiourea (TU) and thiourea dioxide (TUD) was injected intraperitoneally (688.5 and 84.6 mg / kg, respectively). According to the formula proposed by S. Cherkinsky et al., accumulation factor was assessed. On 21 day, the surviving animals were introduced TU and TUD at a dose of LD50, and the death was recorded within 2 weeks.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Aminoiminomethanesulphinic acid
- EC Number:
- 217-157-8
- EC Name:
- Aminoiminomethanesulphinic acid
- Cas Number:
- 1758-73-2
- Molecular formula:
- CH4N2O2S
- IUPAC Name:
- aminoiminomethanesulphinic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- LD50was determined by intraperitoneal injection to white rats of aqueous solutions of the substances by probit analysis and in modification by V.B. Prozorovskiy when observed during 14 days. To characterize the cumulative properties of the two groups of rats 10 in each every day for 20 days, 1/5 LD50TU and TUD was injected intraperitoneally (688.5 and 84.6 mg / kg, respectively). According to the formula proposed by S. Cherkinsky et al., accumulation factor was assessed. On 21 day, the surviving animals were introduced TU and TUD at a dose of LD50, and the death was recorded within 2 weeks.
- Doses:
- 84.6 mg/kg bw
- No. of animals per sex per dose:
- Female+male: 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- >= 418.6 - <= 437.7 mg/kg bw
- Based on:
- not specified
- Mortality:
- The repeated introduction of Thiourea (TU) developed reduced sensitivity to the substance: subsequent introduction of LD50 caused the death of a single animal.
- Clinical signs:
- no data
- Body weight:
- The repeated introduction of thiourea dioxide (TUD) resulted in weight loss much larger than during the introduction of thiourea (TU); the relative weight of most of the internal organs, in contrast, was higher.
- Gross pathology:
- no data
Applicant's summary and conclusion
- Conclusions:
- In single intraperitoneal introduction, thiourea dioxide (TUD) LD50 is 423 ± 14,7 mg / kg, thiourea (TU) is 3442 ± 103,2 mg / kg. The accumulation coefficient of TUD is 1.83 (expressed).
- Executive summary:
Single intraperitoneal introduction of an aqueous solution of thiourea dioxide (tautomer of formamidine sulfinic acid) revealed a LD50 of 423±14.7 mg/kg,
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