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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Relevant (or significant) methodological deficiencies (test item tested in a 40 % aqueous solution)

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1981
Report Date:
1981
Reference Type:
secondary source
Title:
Methanesulfinic acid, Aminoimino, CAS No: 1758-73-2
Author:
OECD SIDS
Year:
2002
Bibliographic source:
OECD SIDS; UNEP Publications

Materials and methods

Principles of method if other than guideline:
The skin irritation potential of the test item was investigated by means of a Patch-test on the abraded and intact skin of rabbits.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped and abraded
Vehicle:
water
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): 40% mixture with water

Duration of treatment / exposure:
4 h
Observation period:
3 days
Reading time points: 24 and 72 h
Number of animals:
6 (Hair-clipped)
6 (abraded)
Details on study design:
TEST SITE
- Type of wrap if used: The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain the test patches in position and to retard the evaporation of volatile substances.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): the material was removed
- Time after start of exposure: 24 h

SCORING SYSTEM: Draize score method

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Remarks:
out of 6 animals
Time point:
other: mean over 24, 48 and 72 h
Score:
1.5
Max. score:
4
Reversibility:
no data
Remarks on result:
other: intact skin; no 48 h data are available; for calculation of mean scores, the 48 values were assumed to be the same as those at 24 h (worst case assumption: persistence of effects seen at 24 h over 48 h)
Irritation parameter:
edema score
Basis:
mean
Remarks:
out of 6 animals
Time point:
other: mean over 24, 48 and 72 h
Score:
0.61
Max. score:
4
Reversibility:
no data
Remarks on result:
other: intact skin; no 48 h data are available; for calculation of mean scores, the 48 values were assumed to be the same as those at 24 h (worst case assumption: persistence of effects seen at 24 h over 48 h)
Irritant / corrosive response data:
-Intact skin (24 h): very slight or well-defined erythema and very slight edema;
-Intact skin (72 h): very slight or well-defined erythema, very slight or slight ischemia and very slight or slight edema;
-Abraded skin (24 h): well-defined or moderate erythema, very slight or slight ischemia (especially on abrasions) and very slight to moderate edema;
-Abraded skin (72 h): well-defined or moderate erythema, slight to distinct ischemia and very slight or slight edema

Applicant's summary and conclusion

Interpretation of results:
other: inconclusive
Remarks:
Criteria used for interpretation of results: EU