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Environmental fate & pathways

Hydrolysis

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Description of key information

Under environmental conditions (pH 7, 25°C) hydrolysis of the test substance takes place in a time frame of weeks.

Key value for chemical safety assessment

Half-life for hydrolysis:
60.8 d
at the temperature of:
25 °C

Additional information

One GLP-study on the hydrolytic degradation for the test substance according to OECD Guideline 111 is available (Miner and Lentz, 2005). The hydrolysis of the substance in sterile buffer solution was investigated at pH 4, 7 and 9 at three different temperatures (50, 25 and 40 °C). This study demonstrated that the test material is hydrolytically stable at pH 4 (estimated DT50 at 25 °C > 1 year) and is susceptible to hydrolysis at pH 7 and 9 (DT50 = 1.7 – 9.4 d) and high temperatures (40 °C, 50 °C). The test substance hydrolyses at a slow to moderate rate under environmental conditions with specific half-lives of 60.8 – 71.4 days (pH 7, 25°C) and 53.7 – 55.0 days (pH 9, 25°C). Nevertheless, hydrolysis can be a route of elimination of the substance from the environment.

The major hydrolysis products observed at pH 7 and pH 9 were formed by amide cleavage to the corresponding carboxylic acid (3,4-dichloroisothiazole-5-carboxylic acid) and the amine (2-aminobenzonitrile).