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EC number: 619-682-1 | CAS number: 224049-04-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 Apr 2005 - 12 Jul 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,4-dichloro-N-(2-cyanophenyl)-1,2-thiazole-5-carboxamide
- EC Number:
- 619-682-1
- Cas Number:
- 224049-04-1
- Molecular formula:
- C11H5Cl2N3OS
- IUPAC Name:
- 3,4-dichloro-N-(2-cyanophenyl)-1,2-thiazole-5-carboxamide
- Reference substance name:
- 3,4-dichloro-2'-cyano-1,2-thiazole-5-carboxanilide
- IUPAC Name:
- 3,4-dichloro-2'-cyano-1,2-thiazole-5-carboxanilide
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Wistar HsdCpb:Wu
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan/Winkelmann GmbH, Borchen, Germany
- Age at study initiation: 10 - 12 weeks
- Weight at study initiation: 161 - 176 g
- Housing: The animals were group caged conventionally in polycarbonate cages on low dust wood granulate bedding (J. Rettenmaier & Sohne, Rosenberg, Germany). The cages of the animals were placed on racks, in ascending group number order. The wood granulate was randomly checked for contaminants at regular intervals and the results have been stored at the Department for Laboratory Animal Services, Bayer HealthCare AG, Wuppertal, Germany. The cages were changed at least once a week. Feed racks and water bottles were not changed. All cage material was washed with hot water which did not contain any detergent or disinfectant.
- Diet: Provimi Kliba 3883.0.15 Maus/Ratte Haltung (Kaiseraugst, Switzerland), ad libitum. Food was withheld prior to dosing.
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ±2
- Humidity (%): 55 ±5
- Air changes (per hr): approx. 10 changes per hour
- Photoperiod (hrs dark / hrs light): 12/12 hrs
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- with the aid of 2% Cremophor EL
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1%, 20% concentrations were tested to ensure the formulations are stable at room temperature. The exact concentration in the vehicle used in the study is not reported.
- Amount of vehicle (if gavage): not reported.
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: The dose was selected based on the stepwise procedure described in the flow charts of Annex 2, OECD guideline 423, with each step using three animals of a single sex (normally females), and evaluating the effect. As the substance was expected to have low toxicity, the highest limit dose of 2000 mg/kg bw was selected as the initial dose. As there was no mortality during the first step, 3 additional rats were treated with the same dose. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- Step 1: 3 females
Step 2: 3 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: Clinical signs and mortality rates were determined several times on the day of administration and subsequently at least once daily for an observation period of at least 14 days. Mortality and in the event of symptoms occurring, nature, duration and intensity were recorded individually.The weight gain of the animals was checked weekly until the end of the study.
- Necropsy of survivors performed: yes.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality
- Mortality:
- During the 14-day observation period, no mortality occurred among females after treatment with 2000 mg/kg bw.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- The necropsies performed at the end of the study revealed no treatment-related findings.
Any other information on results incl. tables
Dose response table:
dose mg/kg bw. | toxicological results* | occurrence of signs | time of death | mortality (%) | ||
(1st) 2000 | 0 | 0 | 3 | - | - | 0 |
(2nd) 2000 | 0 | 0 | 3 | - | - | 0 |
* number of animals which died spontaneously and/or were sacrificed in moribund state / number of animals with signs of toxicity / total number of animals used per group
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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