Registration Dossier
Registration Dossier
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EC number: 223-622-6 | CAS number: 3982-91-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
There are no data for genotoxicity in bacteria (Ames test, in vitro), or in mamalian cells in vitro available.
Thiophosphoryl trichloride hydrolyses in aqueous medium rapidly.
The hydrolysis of a 30% aqueous thiophosphoryl chloride solution in CD3CN was evaluated by NMR spectroscopy. After 2.5 h as main components S=P(OH)2Cl and S=P(OH)3 and minor amounts of O=P(OH)2Cl and H3PO4 were found.
After 9 hours as main component S=P(OH)3 and minor amounts of O=P(OH)2Cl and H3PO4 were detected.
Due to analytical limitations of the method used, hydrogen chloride can not be detected, but the formation of HCl is predicted based on the stoichiometry of the hydrolysis reaction.
Phosphoric acid and hydrogen chloride are strong acids and according Regulation (EC) No 1272/2008 Annex VI Table 3.2 hydrogen chloride is corrosive (C; R35) as well as phosphoric acid (C; R34), (C > 25%). Due to the rapid hydrolysis and corrosivity of hydrolyses products a study with thiophosphoryl trichloride is scientifically not justified.
With phosphoric acid consistent negative results have been obtained in the bacterial systems, while positive results have been obtained in the non-bacterial systems. The positive results were observed at high concentration, but they were considered to be artifacts due to low pH (OECD SIDS for phosphoric acid).
For HCl, a negative result has been shown in the Ames test. A positive result, which is considered to be an artifact due to the low pH, has been obtained in a chromosome aberration test using Hamster ovary cells (OECD SIDS for HCl).
No chromosome aberration test in vitro is available is thiophosphoryl trichloride.
Short description of key information:
No in-vitro genotoxicity studies are available for thiophosphoryl trichloride.
Endpoint Conclusion:
Justification for classification or non-classification
From the available results of in-vitro genotoxicity studies with phosphoric acid and hydrogenchloride (H3PO4 + 3 HCl) a genotoxicity classification for thiophosphoryl trichloride is not justified.
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