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Administrative data

Description of key information

The LC50 (rat, 4h): 140 mg/m³
The LD50 (rat, oral) 750 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: most important information is available
Reference:
Composition 0
Principles of method if other than guideline:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
GLP compliance:
not specified
Test type:
standard acute method
Test material information:
Composition 1
Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
Body weight 180-200 g
Fasting before dosing
Route of administration:
oral: gavage
Vehicle:
vegetable oil
Details on oral exposure:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil.
Doses:
Eight or nine dose levels (no further data)
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
Statistics:
LD50 was calcuclated according to Bliss (1935) and according to Trevan (1927)
Sex:
male/female
Dose descriptor:
LD50
Effect level:
750 mg/kg bw
Based on:
other: calculated according to Trevan (1927) Proc Roy Soc London 101, 483, 712
Sex:
male/female
Dose descriptor:
LD50
Effect level:
700
Based on:
other: calculated according to Bliss (1935) Ann Appl Biol 22134-167
Mortality:
no details given
Clinical signs:
no details given
Body weight:
At the beginning 180-200 g , no further data
Gross pathology:
no data
Other findings:
no data

no data

Executive summary:

Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil (no further details). After a 14-day observation period the LD50 was calculated: LD50(rat) 750 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
750 mg/kg bw
Quality of whole database:
The materials/methods and results are described sufficient for evaluation

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
140 mg/m³

Additional information

Oral

Groups of 10 fasted male and female Sprague Dawley rats or 10 fasted male and female Wistar rats were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil (no further details). After a 14-day observation period the LD50 was calculated for each species with 2 different methods. The resulting LD50 ranged between 700 and 750 mg/kg bw for Sprague Dawley rats and for Wistar tats between 750 and 800 mg/kg bw (Calosi-Esca 1984). Based on these data LD50 (rat, oral) = 750 mg/kg bw is relevant for further considerations.

Inhalation

In none of the available publications considering acute inhalation toxicity detailed description of the method used is available. Chruscielka 1971 and Marhold 1972 reported at least a 4-hour exposure time resulting in LC50 value of 0.14 mg/l for rats and 0.63 mg/l for guinea pig. Galushka published LC50 values for rats, mice and guinea pig of 0.53 mg/l, 0.63 mg/l and 0.4 mg/l , respectively, without details and the National Defense Research Committee cited by RTECS gives a LCL0-value of 3 mg/l for a 10 min exposure. Based on these data the LC50 (rat, 4h) of 0.14 mg/l (140 mg/m³) is chosen on a weight of evidence consideration as relevant.

Dermal

There are no valid data available for thiophosphoryl trichloride. According Annex VI to Regulation (EC) no 1272/2008 no legal classification exists for dermal toxicity regarding the hydrolysis products of thiophosphoryl trichloride.


Justification for selection of acute toxicity – oral endpoint
The most reliable study was used as key study and for classification

Justification for classification or non-classification

Oral

Based on the data above it is proposed to group thiophosphoryl trichloride in category 4 for acute oral exposure (H302).

Inhalation

Based on the above discussed information it is proposed to group thiophosphoryl trichloride in category 1 for acute inhalation exposure (H330).