Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: other route
Remarks:
other: subacute and subchronic
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Methods and results insufficient documented

Data source

Reference
Reference Type:
publication
Title:
Hygienic substantiation of maximum allowable concentration of phosphorus thiotrichloride in water reservoirs
Author:
Tomkiv VM
Year:
1988
Bibliographic source:
Gig. Sanit. Iss 11, 68-70

Materials and methods

Principles of method if other than guideline:
Thiophosphoryl trichloride was applied oral or dermal to albino rats for 30 or 90 days. Tissues were examined histopatologically and histoenzymatically.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: oral and dermal
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Subacute and subchronic exposure
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
Subacute 1/10, 1/50, 1/250 or 1/2000 LD50 oral or dermal,
chronic 1/250, 1/2000 or 1/10000 LD50 oral
No. of animals per sex per dose:
no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Subacute and chronic study:
subacute 1/10, 1/50, 1/250 or 1/2000 LD50 oral or dermal,
chronic 1/250, 1/2000 or 1/10000 LD50 oral
effect on tissue cholinesterase, red cell cholinesterase and plasmacholinesterase; some effects on liver parenchym
and spermatogenese index without effect on spermatogenetic epithel (no further data).

Applicant's summary and conclusion

Executive summary:

Thiophosphoryl trichloride was applied oral or dermal to albino rats for 30 or 90 days. Tissues were examined histopatologically and histoenzymatically. Effects on tissue cholinesterase, red cell cholinesterase and plasmacholinesterase and liver parenchym were observed.