Registration Dossier
Registration Dossier
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EC number: 223-622-6 | CAS number: 3982-91-0
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: subacute and subchronic
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Methods and results insufficient documented
Data source
Reference
- Reference Type:
- publication
- Title:
- Hygienic substantiation of maximum allowable concentration of phosphorus thiotrichloride in water reservoirs
- Author:
- Tomkiv VM
- Year:
- 1 988
- Bibliographic source:
- Gig. Sanit. Iss 11, 68-70
Materials and methods
- Principles of method if other than guideline:
- Thiophosphoryl trichloride was applied oral or dermal to albino rats for 30 or 90 days. Tissues were examined histopatologically and histoenzymatically.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Thiophosphoryl trichloride
- EC Number:
- 223-622-6
- EC Name:
- Thiophosphoryl trichloride
- Cas Number:
- 3982-91-0
- Molecular formula:
- Cl3PS
- IUPAC Name:
- phosphorothioyl trichloride
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral and dermal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Subacute and subchronic exposure
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Subacute 1/10, 1/50, 1/250 or 1/2000 LD50 oral or dermal,
chronic 1/250, 1/2000 or 1/10000 LD50 oral
- No. of animals per sex per dose:
- no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
subacute 1/10, 1/50, 1/250 or 1/2000 LD50 oral or dermal,
chronic 1/250, 1/2000 or 1/10000 LD50 oral
effect on tissue cholinesterase, red cell cholinesterase and plasmacholinesterase; some effects on liver parenchym
and spermatogenese index without effect on spermatogenetic epithel (no further data).
Applicant's summary and conclusion
- Executive summary:
Thiophosphoryl trichloride was applied oral or dermal to albino rats for 30 or 90 days. Tissues were examined histopatologically and histoenzymatically. Effects on tissue cholinesterase, red cell cholinesterase and plasmacholinesterase and liver parenchym were observed.
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