Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Special investigation

Data source

Reference
Reference Type:
publication
Title:
Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3 and their diethyl esters) are anticholinesterase agents directly or on activation
Author:
Segall Y, Quistad GB, Sparks SE, Casida JE
Year:
2003
Bibliographic source:
Chem Res Toxicol 16, 350-356

Materials and methods

Type of study / information:
Effects on enzymes
Test guideline
Qualifier:
no guideline followed

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Thiophosphoryl trichloride (PSCl3) is less active in inhibition of acetylcholin esterase and butyrylcholine esterase than phosphorus trichloride (PCl3) and phosphoryl trichloride (POCl3).

Applicant's summary and conclusion

Executive summary:

Thiophosphoryl trichloride (PSCl3) is less active in inhibition of acetylcholin esterase and butyrylcholine esterase than phosphorus trichloride (PCl3) and phosphoryl trichloride (POCl3).