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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: most important information is available

Data source

Reference
Reference Type:
publication
Title:
Short-term test systems to assess thiophosphoryl chloride standards
Author:
Colosi-Esca D, Snca Z, Barbarino F, Surcel D, Papilian VV
Year:
1984
Bibliographic source:
J. Appl. Toxicol. 4, 230-235

Materials and methods

Principles of method if other than guideline:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
Body weight 180-200 g
Fasting before dosing

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
vegetable oil
Details on oral exposure:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil.
Doses:
Eight or nine dose levels (no further data)
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
Statistics:
LD50 was calcuclated according to Bliss (1935) and according to Trevan (1927)

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
750 mg/kg bw
Based on:
other: calculated according to Trevan (1927) Proc Roy Soc London 101, 483, 712
Sex:
male/female
Dose descriptor:
LD50
Effect level:
700
Based on:
other: calculated according to Bliss (1935) Ann Appl Biol 22134-167
Mortality:
no details given
Clinical signs:
no details given
Body weight:
At the beginning 180-200 g , no further data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil (no further details). After a 14-day observation period the LD50 was calculated: LD50(rat) 750 mg/kg bw.