Registration Dossier
Registration Dossier
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EC number: 223-622-6 | CAS number: 3982-91-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: most important information is available
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-term test systems to assess thiophosphoryl chloride standards
- Author:
- Colosi-Esca D, Snca Z, Barbarino F, Surcel D, Papilian VV
- Year:
- 1 984
- Bibliographic source:
- J. Appl. Toxicol. 4, 230-235
Materials and methods
- Principles of method if other than guideline:
- Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Thiophosphoryl trichloride
- EC Number:
- 223-622-6
- EC Name:
- Thiophosphoryl trichloride
- Cas Number:
- 3982-91-0
- Molecular formula:
- Cl3PS
- IUPAC Name:
- phosphorothioyl trichloride
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Body weight 180-200 g
Fasting before dosing
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Details on oral exposure:
- Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil.
- Doses:
- Eight or nine dose levels (no further data)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
- Statistics:
- LD50 was calcuclated according to Bliss (1935) and according to Trevan (1927)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 750 mg/kg bw
- Based on:
- other: calculated according to Trevan (1927) Proc Roy Soc London 101, 483, 712
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 700
- Based on:
- other: calculated according to Bliss (1935) Ann Appl Biol 22134-167
- Mortality:
- no details given
- Clinical signs:
- no details given
- Body weight:
- At the beginning 180-200 g , no further data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Executive summary:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil (no further details). After a 14-day observation period the LD50 was calculated: LD50(rat) 750 mg/kg bw.
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