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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: most important information is available

Data source

Reference
Reference Type:
publication
Title:
Short-term test systems to assess thiophosphoryl chloride standards
Author:
Colosi-Esca D, Snca Z, Barbarino F, Surcel D, Papilian VV
Year:
1984
Bibliographic source:
J. Appl. Toxicol. 4, 230-235

Materials and methods

Principles of method if other than guideline:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Thiophosphoryl trichloride
EC Number:
223-622-6
EC Name:
Thiophosphoryl trichloride
Cas Number:
3982-91-0
Molecular formula:
Cl3PS
IUPAC Name:
phosphorothioyl trichloride
Details on test material:
no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Body weight 180-200 g
Fasting before dosing

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
vegetable oil
Details on oral exposure:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil.
Doses:
Eight or nine dose levels (no further data)
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
Statistics:
LD50 was calcuclated according to Bliss (1935) and according to Trevan (1927)

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
750 mg/kg bw
Based on:
other: calculated according to Trevan (1927) Proc Roy Soc London 101, 483, 712
Sex:
male/female
Dose descriptor:
LD50
Effect level:
700
Based on:
other: calculated according to Bliss (1935) Ann Appl Biol 22134-167
Mortality:
no details given
Clinical signs:
no details given
Body weight:
At the beginning 180-200 g , no further data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil (no further details). After a 14-day observation period the LD50 was calculated: LD50(rat) 750 mg/kg bw.