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EC number: 213-180-2 | CAS number: 928-70-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was considered not reliable since the documentation of the study was insufficient for assessment. Especially, no details on the test substance composition was provided. Read-across justification: Target substance belongs into the group of substances called xanthates. The xanthates are generally prepared from the reaction of the alkoxide, which reacts with carbon disulphide to give the xanthate. These substances contain common functional group which is dithiocarbonate (-OCSS-). Though they are structural analogues with the target substance. All these analogue substances are also used in similar use application as water solutions. All xanthates decompose in the presence of water. In neutral to alkaline media, they will release carbon disulphide, particular alcohol(s) and carbonates and dithiocarbonates. Carbon disulphide is the major and the most volatile and the most hazardous decomposition product of xanthates. It is also more toxic to human health than the target substance. As the xanthates can be considered as a group of substances which have structural similarity and similar behaviour in contact with water and in the physiological processes, their irritation as well as acute and systemic adverse effects to human health are similar. Therefore, and in order to avoid the unnecessary animal testing, the read-across data from the analogue xanthates is used to evaluate the irritation, and short term and/or long-term toxicological effects of the target substance. As the target substance is an unstable compound, the apparent toxicity reflects to the toxicity of the degradation products. The selection of the most critical degradation products for the hazard assessment are based on the known decomposition reaction of the target substance and based on the physicochemical properties and toxicological properties of the degradation products. The adverse effects through inhalation route are not relevant for the substance itself, which is a solid non-volatile pellet form substance. However, the most serious human health hazards are related to CS2 released from the target substance. Therefore, the formation of carbon disulphide by decomposition is the driving force for human health hazard assessment via inhalation and taken into account in DNEL derivation and in the exposure assessment of the target substance.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Sodium Ethyl Xanthate - Priority Exiting Chemical No. 5
- Author:
- National Industrial Chemicals Notification and Assessment Scheme (NICNAS)
- Year:
- 1 995
- Bibliographic source:
- Australian Government Publishing Service Canberra
Materials and methods
- Principles of method if other than guideline:
- Sodium ethyl xanthate was administered by occlusive application to the shaved abdomen of the rabbits either as 1 g/kg bw of the 100% dry material in a paste formed with water. The animals were observed for 12 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- IUPAC Name:
- sodium O-ethyl dithiocarbonate
- Test material form:
- semi-solid (amorphous): gel
- Remarks:
- migrated information: paste
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Type of coverage:
- occlusive
- Duration of exposure:
- 18 hrs
- Doses:
- 1 000 mg/kg bw
- No. of animals per sex per dose:
- Three rabbits
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- < 1 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: Surviving animal had moderate irritation with oedema and pigmentation of the skin.
- Gross pathology:
- Moderate amount of peritoneal fluid, visceral organs were normal.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Rabbit were exposed to sodium ethyl xanthate for 18 hours. The LD50 value was concluded to be < 1 000 mg/kg bw.
- Executive summary:
This study was conducted for the analogue substance. The study was considered not reliable since the documentation of the study was insufficient for assessment. Especially, no details on the test substance was provided. Thus, this study is used as a weight of evidence in the hazard assessment.
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