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EC number: 213-180-2 | CAS number: 928-70-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Available weight of evidence on chronic toxicity to fish suggest 28-d NOEC (reproduction) value of 0.79 mg/L based on the analogue substance potassium amyl xanthate.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.79 mg/L
Additional information
There are no scientifically valid chronic toxicity data available on the target substance. As there are studies available for the minor constituent and analogue substance potassium amyl xanthate (PAX), these study results were used in CSA as read-across data to evaluate the long-term toxicity of the target substance. As the studies were not considered reliable they were used as a weight of evidence. The read-across justification is presented in Annex I of CSR.
Webb et al. (1976) compared 96-h acute and 28-d chronic toxicities of mining flotation reagents to rainbow trout (Oncorhynchus mykiss, reported as Salmo Gairdneri). The 28-d LC50 on read-across substance PAX was > 1 mg/L at at pH 8 and temperature of 10.5 oC, and it had lowest chronic toxicity of the four xanthates tested. Except for PAX, the observed difference in toxicity for the same compounds between (acute) static and (chronic) flow-through bioassays was up to two orders of magnitude greater in the (chronic) flow-through tests. Inconsistently, out of the four xanthates tested, PAX had the highest acute toxicity but lowest chronic toxicity. As insufficient details on test materials and methods were available to assess the method applied, and no information on statistics and controls were reported in the publication, the results are rated as reliable with restrictions.
Leduc et al.(1975) examined chronic aquatic toxicity of xanthates, arsenic compounds and cyanide to rainbow trout (Oncorhynchus mykiss, reported as Salmo Gairdneri). The read-across substance PAX was concluded to cause liver necrosis already at concentration of 0.07 mg/L level and additionally disturb development of eggs in the ovary at the 0.79 mg/L level of exposure. The study was conducted for 28 days in a flow-through system at temperature of 10.5 oC. As insufficient details on test materials, methods, statistics and validation criteria were reported, the results are rated as not reliable.
In conclusion, the weight of evidence obtained for chronic toxicity of potassium amyl xanthate would suggest NOEC value of 0.79 mg/L to fish (reproduction).
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