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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The study was not regarded reliable, since only summary from IUCLID 2000 data set is available and details on the test substance and study results are not available for assessment. However, the study was conducted according to OECD guideline 404. Read-across justification: Target substance belongs into the group of substances called xanthates. The xanthates are generally prepared from the reaction of the alkoxide, which reacts with carbon disulphide to give the xanthate. These substances contain common functional group which is dithiocarbonate (-OCSS-). Though they are structural analogues with the target substance. All these analogue substances are also used in similar use application as water solutions. All xanthates decompose in the presence of water. In neutral to alkaline media, they will release carbon disulphide, particular alcohol(s) and carbonates and dithiocarbonates. Carbon disulphide is the major and the most volatile and the most hazardous decomposition product of xanthates. It is also more toxic to human health than the target substance. As the xanthates can be considered as a group of substances which have structural similarity and similar behaviour in contact with water and in the physiological processes, their irritation as well as acute and systemic adverse effects to human health are similar. Therefore, and in order to avoid the unnecessary animal testing, the read-across data from the analogue xanthates is used to evaluate the irritation, and short term and/or long-term toxicological effects of the target substance. As the target substance is an unstable compound, the apparent toxicity reflects to the toxicity of the degradation products. The selection of the most critical degradation products for the hazard assessment are based on the known decomposition reaction of the target substance and based on the physicochemical properties and toxicological properties of the degradation products. The adverse effects through inhalation route are not relevant for the substance itself, which is a solid non-volatile pellet form substance. However, the most serious human health hazards are related to CS2 released from the target substance. Therefore, the formation of carbon disulphide by decomposition is the driving force for human health hazard assessment via inhalation and taken into account in DNEL derivation and in the exposure assessment of the target substance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report Date:
1987

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified

Test system

Preparation of test site:
not specified
Vehicle:
physiological saline
Amount / concentration applied:
500 mg test substance + 0.15 ml 0.9% NaCl
Duration of treatment / exposure:
4 hours

Results and discussion

In vivo

Results
Irritation parameter:
other:
Basis:
mean
Remarks on result:
other: corrosive

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive)
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Potassium isobutyl xanthate (500mg) was applied in the volume of 0.15ml on the flank of rabbit. The test substance was classified as corrosive.
Executive summary:

This study was performed for analogue substance. The study was regarded not reliable, since available document is insufficient for assessment. However, the study was conducted according to the OECD 404 guideline. This study is used as weight of evidence in the hazard assessment.

The classification of this substance is based on the pH, which is above > 11.5. Thus, classification for Skin Corr. 1A is warranted.