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EC number: 212-084-8 | CAS number: 760-93-0
Erythema and Eschar formation
Group total score
Primary irritation index: Group total score/24 = 4.8
Reevaluation according GHS criteria
Only animals with shaved skin were evaluated
Classification according GHS: Category 2 (Erythema < 2,3; Edema > 2,3)
Exposure time: 24 hours instead of 4 hours
Study was too short for a clear statement of reversibility because there was no observation after 72 hours.
In a skin irritation study (1984) acc. Journal officiel skin irritation test with 6 New Zealand White rabbits and an exposure time of 24 h (occlusive) methacrylic anhydride was irritating to skin. Observation time was too short for a clear statement of reversability. (Only 72 h instead of 14 h). Therefore methacrylic anhydride has to be classified acc. OECD GHS criteria as follows: Skin irritating Category 2
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