Registration Dossier

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in mammalian cells
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Justification for type of information:
An in vitro gene mutation test with Methacrylic anhydride (MAAH) is unnecessary, because relevant in vitro and in vivo data are available on methyl methacrylate (MMA) and other methacrylates for this endpoint, which are used in a category read-across approach. The anhydride and ester are similar in stucture and polarity and share the same primary metabolite/hydrolysis product, methacrylic acid. see aatached justification of Albertini (2017)

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion