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EC number: 212-084-8 | CAS number: 760-93-0
LC50 ESTIMATION AND CONCLUSIONS
The LC50 of Methacrylic Anhydride for acute 4-hour inhalation toxicity in male and female rats observed for a period of 15 days, was estimated to be higher than the achieved test concentration of 2.081 mg/I air (chemically determined mean test atmosphere concentration, approx. three quarters of which were aerosol and one quarter vapour). In addition, the LC50 is expected to be lower than 5 mg/lair due to the 10% mortality at 2.081 mg/I air in combination with severe clinical signs, initial body weight loss and macroscopical findings.
There was one premature death during the course of the study. All animals showed the following clinical signs with marked severity during and/or after the inhalation exposure: Laboured respiration, breath sounds [rales], salivation, a decrease in spontaneous activity and ruffled fur. In addition, the findings of moderate or marked red secretion from the nose and hunched posture
were seen in all animals and one male animal was seen slightly emaciated on four consecutive days, and one female animal was seen with a half closed eyelid on test day 1. After the exposure, in general the severity of the clinical signs noted diminished, and towards the end of the observation period all surviving animals were free from clinical signs. Marked body weight losses were seen in all animals from test day 1 to 4. Thereafter, the body weight gain returned to normal in most of the animals. At necropsy, eight of ten animals showed incompletely collapsed lungs. In six animals darkred or reddish foci were noted in the lungs and three females showed darkred discoloration of the lungs.
Methacrylic anhydride was tested in an acute inhalation toxicity test acc. OECD 403. The purpose of this acute 4-hour inhalation toxicity study was to assess the acute inhalation toxicity of Methacrylic anhydride when administered to rats by nose-only, flow-past inhalation exposure for a single continuous 4-hour period, followed by an observation period of 14 days. The LC50 of Methacrylic anhydride obtained in this study, was estimated to be greater than the test concentration of 2.081 mg/I air (chemically determined mean test atmosphere concentration). In addition, the LC50 is expected to be lower than 5 mg/I air due to the 10% mortality at 2.081 mg/I air, severe clinical signs, initial body weight loss and macroscopical findings.
This study is classified as acceptable. This study satisfies the requirement for testing the acute inhalation toxicity.
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