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Description of key information

Primary Irritation Index: 2.26 (QSAR prediction)

MMAS: 49.5 (QSAR prediction)

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation / corrosion, other
Remarks:
Skin Irritation in vivo (from QSAR prediction)
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Guideline:
other: REACH Guidance on QSAR
Specific details on test material used for the study:
SMILES: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{+}
Irritation parameter:
primary dermal irritation index (PDII)
Score:
2.26
Interpretation of results:
GHS criteria not met
Conclusions:
Not irritating.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation, other
Remarks:
eye irritation in vivo (from QSAR prediction)
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Guideline:
other: REACH guideline on QSAR
Specific details on test material used for the study:
SMILES: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{+}
Irritation parameter:
other: MMAS (Modified Maximum Avarage Score)
Time point:
other: not specified
Score:
49.5
Interpretation of results:
Category 2B (mildly irritating to eyes) based on GHS criteria
Conclusions:
The value obtained for MMAS of the prediction was 49.5, which indicates that the compound is midly toxic considering that the maximum value of damage in cornea conjunctive and iris is 110
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

A primary Irritation Index value of 2.26 was prediction. According to the CLP criteria susbtance is not irritating (skin).

The value obtained for MMAS of the prediction was 49.5 which indicates that the compound is midly toxic considering that the maximum value of damage in cornea conjunctive and iris is 110. According to the CLP criteria substance is not irritating (eyes)

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