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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics in vivo
Remarks:
Dermal Toxicokinetic
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Objective of study:
absorption
Qualifier:
according to guideline
Guideline:
OECD Guideline 417 (Toxicokinetics)
Qualifier:
according to guideline
Guideline:
other: OECD 428
GLP compliance:
no
Species:
other: Human, Human skin and rats, human skin preparations (surgically removed skin from the abdomen), pig, rabbit, rat.
Route of administration:
dermal
Details on absorption:
Taking into account the OECD 417 and the OECD 428, the values ​​obtained with QSAR Toolbox (QT) are reported as % of absorption.

The calculated value reported is 1.42% of absorption; considering the standards, the model is made of skin from which the substance in question is used from 1 to 5 mg / cm2. This means that, if we assume a scenario where a human being of 80 Kg of weight, with an approximate skin extension of 2m2, and an exposure level of 5mg / cm2 (worse of the scenarios paragraph 15 guide 428); the study subject will have an absorption level of 17.75 mg / Kg.

If we compare this value with the lethal dermal dose (2130 mg/Kg), the dose obtained from the absorption in a total exposure in contact with the skin is not representative of a risk.
Conclusions:
The calculated value reported is 1.42% of absorption; considering the standards, the model is made of skin from which the substance in question is used from 1 to 5 mg / cm2. This means that, if we assume a scenario where a human being of 80 Kg of weight, with an approximate skin extension of 2m2, and an exposure level of 5mg / cm2 (worse of the scenarios paragraph 15 guide 428); the study subject will have an absorption level of 17.75 mg / Kg.

If we compare this value with the lethal dermal dose (2130 mg/Kg), the dose obtained from the absorption in a total exposure in contact with the skin is not representative of a risk.

Description of key information

Dermal Absorption: 1.42 %

Key value for chemical safety assessment

Absorption rate - dermal (%):
1.42

Additional information