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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

LOAEL= 94.7 mg/kg bw/day (QSAR prediction).

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Link to relevant study records
Reference
Endpoint:
short-term repeated dose toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Guideline:
other: REACH Guidance on QSARs R.6
Specific details on test material used for the study:
SMILES: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{+}
Key result
Dose descriptor:
LOAEL
Effect level:
94.7 mg/kg bw/day (nominal)
Based on:
not specified
Basis for effect level:
other: not specified
Key result
Critical effects observed:
not specified
Conclusions:
LOAEL= 94.7 mg/kg bw/day. According to this value and the table 3.9.3. of the CLP Regulation, classification STOT RE-2 is applicable.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LOAEL
94.7 mg/kg bw/day
Quality of whole database:
Toxicity of the target chemical (94.7 mg/kg bw/day (nominal)) is predicted by QSAR "Modelo QSAR 180404 LOAEL Gluconato". The target chemical FALLS within applicability domain of the prediction. Reliability 2.

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

LOAEL= 94.7 mg/kg bw/day. According to this value and the table 3.9.3. of the CLP Regulation, classification STOT RE-2 is applicable.