Copper di-D-gluconate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference

Title:

Prediction of LD50 in rat (dermic) for copper di-d-gluconate

Year:

2018

Bibliographic source:

Modelo QSAR 180404 DL50 Dermica Gluconato

Report date:

2018

Materials and methods

Test guideline

Guideline:

other: REACH guidance on QSAR R6

Test material

Test material information

Constituent 1

Reference substance name:

Copper di-D-gluconate

EC Number:

208-408-2

EC Name:

Copper di-D-gluconate

Cas Number:

527-09-3

Molecular formula:

C12H22CuO14

IUPAC Name:

copper(2+) bis(2,3,4,5,6-pentahydroxyhexanoate)

Test material form:

solid

Specific details on test material used for the study:

SMILE: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{+}

Results and discussion

Effect levels

Key result

Dose descriptor:

LD50

Effect level:

2 130 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

DL50= 2130 mg/kg. Substance does not classify as Acute Toxic Dermal in any category.