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Description of key information

EC3= 5.08% This value is predicted by a QSAR Model.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation, other
Remarks:
skin sensitisation in vivo (LLNA) (From QSAR prediction)
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Guideline:
other: REACH Guidance on QSARs R.6
Specific details on test material used for the study:
SMILES: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{+}
Key result
Parameter:
EC3
Value:
5.08
Interpretation of results:
Category 1B (indication of skin sensitising potential) based on GHS criteria
Conclusions:
Toxicity of the target chemical (5.08 %) is predicted by QSAR "Modelo QSAR 180409 Sensitisation LLNA E3 Gluconato".
In conclusion, EC3 value > 2 %; based on GHS criteria the substance has skin sensitising potential (Skin Sens 1B).
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The value obtained for Skin Sensitsation of the prediction value (EC3) was 5.08%. According to GHS criteria, EC3 value > 2 % , the substance must be classified as a skin sensitiser 1B.

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