Registration Dossier
Registration Dossier
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EC number: 208-408-2 | CAS number: 527-09-3
Endpoint summary
Administrative data
Description of key information
EC3= 5.08% This value is predicted by a QSAR Model.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Remarks:
- skin sensitisation in vivo (LLNA) (From QSAR prediction)
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Guideline:
- other: REACH Guidance on QSARs R.6
- Specific details on test material used for the study:
- SMILES: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P-}(O)C(=O)O{-}.[Cu]{+}
- Key result
- Parameter:
- EC3
- Value:
- 5.08
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- Toxicity of the target chemical (5.08 %) is predicted by QSAR "Modelo QSAR 180409 Sensitisation LLNA E3 Gluconato".
In conclusion, EC3 value > 2 %; based on GHS criteria the substance has skin sensitising potential (Skin Sens 1B).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The value obtained for Skin Sensitsation of the prediction value (EC3) was 5.08%. According to GHS criteria, EC3 value > 2 % , the substance must be classified as a skin sensitiser 1B.
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