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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March - May 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
test item is unstable in water, therefore the hydrolysis product PMA was tested; refer to analogue justification provided in IUCLID section 13
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Specific details on test material used for the study:
- Description: white powder
- Batch number: 8M30N
- Storage conditions: room temperature in the dark upto 04 April 2008, thereafter at approximately 4°C, over silica gel, in the dark
Water solubility:
8.83 g/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
Remarks on result:
other: results of preliminary test
Key result
Water solubility:
8.56 g/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
8.56
Remarks on result:
other: results of main test
Conclusions:
The water solubility of the test material has been determined to be 8.56 g/ at 20.0 ± 0.5°C and a pH-value of 8.56.
Executive summary:

The study was conducted according to EC method A.6, using the shake-flask method. In conclusion, the water solubility of the test item was determined to be 8.56 g/L at 20°C. The pH value was found to be 8.56

Description of key information

As the substance to be registered, PMDA, is unstable in water, the corresponding hydrolysis product Pyromellitic acid (PMA) was tested. The study was conducted according to EC method A.6, using the shake-flask method. In conclusion, the water solubility of PMA was determined to be 8.56 g/L at 20°C. The pH value was found to be 8.56. In addition, the estimated water solubility of PMDA is reported in literature to be approx. 130 mg/l at 25°C.

Key value for chemical safety assessment

Water solubility:
8.56 g/L
at the temperature of:
20 °C

Additional information

Source: GLP-report