Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-898-9 | CAS number: 89-32-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- Physical chemical data and data from the toxicological data package may be used to predict the potential ADME characteristics of PMDA. The low toxicity of PMDA in repeat dose studies also lend support to mteabolites of low to no appreciable toxicity.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The physical chemical characteristics of PMDA and the data from the repeat dose toxicity study clearly suggest and demonstrate that PMDA is likely to be readily absorbed, distributed and excreted with limited bioaccumulation. The data suggest that the liver is a target organ and that enhanced metabolism is likely to occur, although the toxicity of metabolites is likely to be limited as in the genotoxicity studies metabolic activation was without demonstrable effect. Considering these attributes, the most likely route of excretion would be primarily via the urine and secondarily the faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
