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EC number: 201-898-9 | CAS number: 89-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Results of element analysis: C: 55.1% H: 0.9% 0:44.0%
- Molecular weight: 218.1
- CAS number: 89-32-7
- Supplier: Mitsubishi Gas Chemical Company Inc.
- Lot number: 5X07 A
- Purity: Test item 99.92%
The test item was treated as 100% in purity. - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- 5, 10, 20 and 30 min. after preparation of samples
- Buffers:
- Purified water was used as test medium (pH 7); no further buffer solutions were tested due to the chemical structure of the test item (dianhydride), However, as eluent for HPLC-analysis: buffer solution pH 2 (0.2 mol/L hydrochloric acid was adjusted to pH 2.0 with 0.2 mol/L potassium chloride solution) was used.
- Estimation method (if used):
- no estimation conducted
- Details on test conditions:
- See section "any other information on materials and methods ....".
- Duration:
- 30 min
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 1 000 mg/L
- Number of replicates:
- not given
- Positive controls:
- yes
- Negative controls:
- yes
- Preliminary study:
- The pre-test was performed at pH 2 and 7.4. In the measurement of UV-spectrum, the UV-spectrum measured immediately after the preparation of 5 mg/L solution (purified water) of PMDA has shown the same shape as that of pyromellitic acid. The UV spectra after 5, 10, 20 and 60 min from the preparation have also shown the same shape as that of pyromellitic acid. Therefore, it was considered that PMDA was converted to pyromellitic acid in water.
In the HPLC analysis for 100 mg/L solutions of PMDA, the detected peak was so similar to the peak of pyromellitic acid that water content in the test item solution was large. From this result, it was considered that the hydrolysis rate ofPMDA became so fast that water content in the test item solution was large, and that PMDA was converted to pyromellitic acid. Then, the UV spectrum measured immediately after the preparation of PMDA solution prepared with water was shown the same shape as that of pyromellitic acid. Therefore, it was considered that PMDA was easily converted to pyromellitic acid. Unknown peaks were so large that the content rate of acetonitrile in the test item solution was large. From this result, it was considered that the hydrolysis rate of PMDA became so slow that the content rate of acetonitrile in the test item solution was large. In the both of ion suppression chromatography and ion pair chromatography, the amount of pyromellitic acid produced from PMDA was almost 100% to the theoretical amount. Therefore, it was confirmed that pyromellitic acid was produced from PMDA.
In conclusion, based on the results of this pre-test, the main study was performed at pH 2 and 25°C. The main test was stopped after 30 minutes. - Transformation products:
- yes
- No.:
- #1
- % Recovery:
- 0
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 30 min
- Remarks on result:
- other: test stopped after 30 minutes due to quantitative hydrolysis of the test item
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- < 20 min
- Type:
- not specified
- Results with reference substance:
- the hydrolysis product PMA was tested as reference in UV- and HPLC-analysis to identify/confirm the chemical structure of the hydrolysis product
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item PMDA is unstable in water and hydrolyzes quickly in contact with water. Its half-life time t(1/2) in purified water is less than 20 minutes at 25°C.
- Executive summary:
Pre- and main test were both performed in accordance with OECD no. 111. Based on the chemical structure (dianhydride), it was assumed that hydrolysis of PMDA to PMA will be fast. In the pre-test, it was confirmed that PMDA was completely hydrolyzed after one hour.
In the main test, the UV spectrum of PMDA solution prepared with acetonitrile/water (1/1 v/v) was different from that of PMDA solution prepared with acetonitrile immediately after the preparation, and was come close to that of pyromellitic acid solution prepared with acetonitrile/water (1/1 v/v) with time, and then was shown the same shape as that of pyromellitic acid solution after 20 min from the preparation of PMDA solution. The UV spectrum for PMDA solution prepared with water was shown the same shape as that of pyromellitic acid solution prepared with water immediately after the preparation Therefore, it is considered that PMDA was rapidly converted to pyromellitic acid in water and that the half-life of the test item is less than 20 min. In conclusion, the test item PMDA is unstable in water and hydrolyzes quickly in contact with water. Its half-life time t(1/2) in purified water is less than 20 minutes at 25°C.
Reference
Description of key information
The test item PMDA is unstable in water and hydrolyzes quickly in contact with water to PMA. Its half-life time t(1/2) in purified water is less than 20 minutes at 25°C.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 20 min
- at the temperature of:
- 25 °C
Additional information
Source: GLP-report
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